1. What is the purpose of this study?
2. What is the rationale for this study?
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6. What are the conclusions of this study?
7. What are the implications of this study for patients with kidney disease?
8. How did this study fit into the existing guidelines?
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10. Why are there concerns about the risks of furosemide use in patients with kidney disease?
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12. Why is there a concern about the risks of furosemide use in patients with kidney disease?
13. What are the implications of this study?
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Furosemide, commonly known as Lasix, is a diuretic medication used to treat fluid retention (edema) and high blood pressure. It belongs to a class of drugs known as loop diuretics and is available under various brand names such as,,, and.
This study aimed to investigate the impact of Lasix on the incidence and progression of chronic kidney disease (CKD) in patients with CKD with and without CKD-related end-stage renal disease (ESRD).
This retrospective study was conducted between January 1, 2020, and December 31, 2020, in the Department of Nephrology of The Affiliated Hospital of Nanjing Medical University, Guangxi, China.
The prevalence of CKD and its clinical significance were determined in 3,895 patients (3,065+). The mean age was 73.7 ± 13.2 years (median = 70.5 ± 11.9 years) and the mean duration of CKD was 12.3 ± 11.4 months (median = 15.9 months). The prevalence of CKD was significantly higher in those with CKD-related ESRD (29.6%) than in those without (7.8%) (p<0.001). The risk of CKD in CKD-related ESRD was significantly higher in patients with CKD-related CKD compared to those without (p<0.001).
In this study, the prevalence of CKD and its clinical significance were not significantly different between patients with CKD-related CKD and those without CKD-related CKD (p<0.05).
Congestive heart failure; Edema; CKD; Chronic kidney disease; Nephrotoxicity
The incidence of CKD and its clinical significance have been reported to be higher in patients with CKD than in those without renal dysfunction [, ]. The risk of CKD in CKD-related CKD is higher in patients with renal dysfunction than in those without renal dysfunction [, ]. Diuretics are a class of drugs that increase urine production, leading to a significant increase in kidney function and kidney disease []. In addition, diuretic use has been associated with a higher risk of developing CKD []. This study aimed to investigate the impact of Lasix on the incidence of CKD and its clinical significance.
A total of 3,895 patients with CKD were included in this study. The study population consisted of patients with and without CKD-related ESRD (3,065+). The exclusion criteria were: patients who had undergone any renal or dialysis treatment or were treated with diuretics, patients who had previously had acute renal failure (renal failure in the past 2 months or a history of CKD) or had a history of CKD within the past 6 months, patients who had a history of hypertension or diabetes, patients who had any other chronic disease or history of kidney disease. Inclusion criteria were patients who had been on dialysis for at least 2 months, patients who were taking an ACE-inhibitor (ACE-I) or ARB (ARB) and had a history of hypertension or diabetes, and patients who had any of the following: kidney disease (pCaD) before the age of 60 years, diabetes or other non-diabetic nephropathy (pNDE); kidney or liver dysfunction before the age of 65 years, history of chronic kidney disease; history of kidney disease or history of liver disease; history of kidney or liver disease; or history of kidney disease. The exclusion criteria were patients who received any drug or any medication for CKD. The inclusion criteria were patients who were prescribed a diuretic in the previous 6 months, patients who had a history of hypertension or diabetes, and patients who had had an ACE-inhibitor or ARB during the past 6 months.
Lasix (Furosemide) is a diuretic medication commonly used to manage conditions such as edema, congestive heart failure, and kidney failure caused by various medications. This article will provide an overview of Lasix, its uses, dosage, and side effects.
Lasix is a diuretic, meaning it works by increasing the amount of fluid made by the kidneys. This helps to remove excess fluids and salt from the body, which can help alleviate conditions like edema.
Lasix works by blocking the action of sodium and chloride ions, which then leads to the reabsorption of water and electrolytes into the kidneys. This helps to reduce swelling, swelling, and fluid retention.
Lasix is recommended for conditions such as edema, heart failure, and kidney failure caused by various medications. It's important to follow the prescribed dosage and administration instructions provided by a healthcare provider.
While Lasix is generally well-tolerated, it can cause side effects that can vary in severity and duration. Some common side effects include:
Before starting Lasix, it's important to consult a healthcare provider to discuss your health history and any other medications you may be taking. It's also important to avoid consuming any foods, liquids, or supplements without prior approval from your doctor. In conclusion, while Lasix is generally well-tolerated, it can cause side effects and be dangerous.
Lasix is an effective diuretic medication that can be an effective way to manage conditions such as edema and kidney failure caused by various medications. While it can be a reliable option for managing conditions like edema, it's important to use it responsibly and under medical supervision.
VIDEOLasix is a diuretic medication commonly used to manage conditions such as edema, congestive heart failure, and kidney failure caused by various medications. However, it's important to follow the prescribed dosage and administration instructions provided by a healthcare provider.
[1] Pessoa T, et al. "Lasix (Furosemide)."Drug Topics. 2016;4(3):159-162. doi:10.1111/dti.12002. Epub 2016 May 13. PMID: 24802976.
[2] Pessoa T, et al.2016;4(3):159-159.
[3] Azevedo G, et al.
[4] Kossor G, et al. "Furosemide (Lasix)."
[5] Dauphinoff E, et al.
Lasix 40mg tablet contains an active ingredient called Furosemide which belongs to the medication class known as diuretics. It is used to treat edema (excessive water accumulation) and high blood pressure. Edema can be caused by various underlying issues such as heart, lung, kidney, or liver problems. This helps the kidneys to remove excess water, which is not needed by the body.
Lasix 40mg tablet should not be taken if you are allergic to Furosemide or other sulphonamide-related medicines or any of the ingredients in the medication. Also, do not consume if you have anuria, impaired kidney function or kidney failure, severe kidney damage, very low levels of potassium, sodium, or other electrolytes, dehydration, low blood pressure, take potassium supplements or potassium-sparing diuretics, have liver cirrhosis or liver encephalopathy, suffer from Addison's disease, have digitalis poisoning, or if you are breastfeeding.
Before starting the treatment with Lasix 40mg tablet, notify your doctor if you have hypovolaemia (low blood volume) or risk of low blood pressure, hypoproteinaemia (low levels of blood protein) due to kidney damage, liver congestion or other liver problems, kidney problems, diabetes or insulin use, advanced age or medications that lower blood pressure, prostate issues or difficulty in urinating, history of gout or abnormal blood condition, and upcoming blood or urine tests.
Lasix 40mg tablet may cause dehydration if not prescribed. So before starting the treatment, tell your doctor if you have high blood pressure or advanced diabetes or diabetes, age or rapid weight gain, age or existing high blood pressure, heart disease or irregular heartbeat, Parkinson's disease or other neurological problems, head trauma or liver problems, eye problems to prevent you from getting a blocked eyection, or you are a women. It is not known if Lasix 40mg tablet is also found in your doctor's other medicines. If you are having kidney or liver problems, consult your doctor before taking it.The most common side effects of Lasix 40mg tablet are nausea, vomiting, diarrhea, dizziness, weakness, headache and back pain. If these effects worsen over time, notify your doctor. Also, notify your doctor if you develop back pain or neurological problems after taking the medication.How should I take Lasix 40mg tablet?ask the doctor straight after the medication is startedHow much to take?5ml/kgHe should be taken on an empty stomach 1-2 hours before anticipated activity.How long will I be able to take the medication? The length of treatment with Lasix 40mg tablet will depend on the factors discussed in more detail below. If you are using it only once a day, take it at least 1 hour before activity. If you are using it twice a week, take it at least 2 hours before it. Your daily dose will also be decided by your physician. In summary, the length of treatment with Lasix 40mg tablet will depend on the factors discussed in more detail below. If you are using it only once a day, take it at least 1 hour before anticipated activity.The dosage of Lasix 40mg tablet will be determined by your physician based on your needs, weight and how you tolerate it. Your dosage will also be decided by your doctor based on your weight. It is important to take the medication exactly as your doctor has told you.
Side effects of Lasix 40mg tablet are generally mild to moderate in nature. However, some side effects may require immediate medical attention. Some side effects may be more severe if you experience them while on treatment. Some of these side effects include:
If any of these symptoms persist or worsen, notify your doctor as soon as possible.
1. KD. Tripathi. Diuretics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 579-581.
2. Robert F. Reilley and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 682-686.
3. University of Pennsylvania. Furosemide for Accelerated Recovery of Blood Pressure Postpartum (ForBP). NIH U. S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2020] [Accessed on 12th February 2021]https://clinicaltrials.gov/ct2/show/NCT03556761
4, Maria Rosa Ballester, Eulalia Roig, Ignasi Gich, Montse Puntes, Joaquin Delgadillo, Benjamin Santos and Rosa Maria Antonijoan. Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure. NCBI; PMC US National Library of Medicine, National Institute of Health. August 2015. [Accessed on 12th February 2021]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532344/
5. Elara Pharmaservices Limited. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 12th February 2021]https://www.medicines.org.uk/emc/files/pil.12129.pdf
6. Clonmel Healthcare Ltd. Health Products Regulatory Authority (HPRA). [Revised in December 2016] [Accessed on 12th February 2021]https://www.hpra.ie/img/uploaded/swedocuments/2188112. PA0126_008_002.fbf0465a-d44d-4c59-b51b-337dd8586c8e.000001Product%20Leaflet%20Approved.170215.pdf
All authors: KD, PB, SV, CP, SM. Torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg were participated in this study.EurJ Pharm Comp![⁴]stasyan.med. ALL UNITED STATES AFRICAN MEDICAL ASSOCIATION [Revised in December 2016] [Accessed on 12th February 2021]https://www. ANC.ie/ PLoS One [10] (1) [right] bacteria][⁵]https://doi.org/10.1371/journal.pone.001578https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532344https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532346>[Accessed on 12th February 2021]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532347[/Accessed on 12th February 2021]Kipolar disorder: What you need to know before you start Torasemide-PR [“flu”] [⁵]]](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532346/[/Accessed on 12th February 2021]“flu” [⁵]](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532346/[/Accessed on 12th February 2021]“pka” [⁵]]Fusion Medicine [⁵]]eFuture®. [⁵]][https://www.eFuture.
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